You chaps all learnt on dt shifters like I did- it's our age. What about Teh Kidz?
I'm probably enough of a kid in this context. I learned on mountain bikes with friction thumbies, and later progressed to the much cooler indexed version on my brother's bike when he wasn't watching.
As I see it, it's two different issues:
Lack of indexing (do DT shifters even come in indexed?) is about hearing and mechanical sympathy, divided by the number of gears involved. While the shifters on my recumbent have switchable indexing, I find that I can't hear well enough to trim 9-speed properly in most traffic conditions, sometimes resulting in unexpected jumps when I put the power on.
The other issue is reaching down to the shifter. I expect most people can learn to do this just fine, though if there's dyspraxia involved, that sets my alarm bell ringing. I don't know any dyspraxics who are particularly happy about riding one-handed, and changing gear while crouching down and riding one-handed is a lot more involved than indicating or scratching your nose. If shifting is faffy or hazardous, you'll change gear less frequently. Whether that's a problem is going to depend on your terrain and riding style - I wouldn't go near DT shifters with a barge pole, for the simple reason that I change down whenever I stop to reduce the stress on my knee when setting off.
There's the side issue of shifters showing you what gear you're in: Down-tubes, bar-ends and thumbies do in a nice analogue, physical way, but that may be less intuitive to a dyspraxic.
I like trigger shifters, bar-ends on appropriately shaped bars, and would probably be okay with STIs if it weren't for the ludicrous braking arrangement. I don't like grip shifters, but that's a personal preference thing - decent ones work well enough. Friction shifting is for front mechs and mechanical emergencies only.
Butterfly bars ftw