Yes, Santana went to 160mm OLD for stronger rear wheels and used 73mm BB shells. The wider BB shells allowed wider-spaced and bigger chain-stays and a bigger bottom tube to be fitted in pursuit of frame stiffness. The chainwheels needed to be pushed out to clear the chain-stays and nominally to line up with the cassette. Normal road triple/ tandem chain line is around 45mm, Santana is about 60mm, so the front mech needs to sit further out, otherwise it can’t shift over all the chainrings.
Sensitivity to Q-factor is very individual. Some folk don’t notice and ride anything interchangeably. Others are delicate flowers and get sore knees from big alterations, particularly when going wider. As a rider’s stance widens, usually their feet point outwards more and their cleats need to be adjusted to match. I am one of those flowers.