Vin Cox rode a Genesis Croix de Fer equipped with an Alfine 8 hub RTW in 2010, setting a new record in the process.
https://www.bikeradar.com/news/vin-cox-sets-new-round-the-world-record/He used a Croix de Fer frameset (which isn't IGH-dedicated, normally being used with derailleur gears ) so that in the event of the IGH giving trouble, he'd be able to use a more readily available derailleur rear wheel instead; I think changing wheels is OK but changing framesets/bikes might fall foul of the RTW rules. The hub did the full trip without incident, so in the event this wasn't necessary.
Heavy loads are mainly a problem from the POV of gear range. Alfine 8 is a better hub than (say) Alfine 11 in many respects, but it has less evenly/more widely spaced gears, and a narrower overall gear range. You can fit two chainrings (provided you use a tensioner) and address one or other issue if you want, but unless there are long hills/steep hills/heavy loads probably you won't need to bother.
IMHO for several reasons the hub works best if you set gear 5 or gear 6 as the 'tapping along' gear, which you would normally use on the flat with no wind, or perhaps as a singlespeed gear
cheers