Yes, that's exactly right Kim. U2 pilots pre-breathe 100% oxygen for an hour pre-flight, and breathe pressurised 100% oxygen in flight. That's still not sufficient to avoid decompression sickness; U2 pilots have suffered DCS in flight on several recorded occasions over the last 30 or so years, as missions have got longer and more complex.
A fairly recent modification to the aircraft has improved the pressurisation so that the cabin altitude is much lower than it once was - it's now around 15,000' rather than the 30,000' it used to be. While that should allow a normal airmix supply to be used, the risk of depressuristion means that they still use the suits and 100% oxygen.