I have a hiatal hernia and chronic acid reflux, for which I take a proton pump inhibitor, to wit Pantoprazole. Recently my GP doubled the dose, because I had scalded my oesophagus eating ramen too hot and with the periodic acid wash it wasn't healing. Recently too I've noticed that my quads hurt more and longer after a ride.
Mr. Google just now turned up an
NIH article in which the following appeared:
Literature indicates that a PPI-induced reduction in acidity of the gastrointestinal tract can decrease the absorption of, amongst others, magnesium. Low levels of magnesium are associated with impaired muscle function. This unwanted side-effect of PPIs on muscle function has been described in different disease backgrounds. Furthermore, magnesium is necessary for activation of vitamin D. Low vitamin D and magnesium levels together can lead to increased inflammation...
Would a magnesium supplement improve things, or does the panel think that 80 mg Pantoprazole/day would be too slight to cause such a noticeable effect?
I'd add that I don't like taking so much because PPIs aren't exactly desirable in someone with CAD, stents, clopidogrel etc. Then again, oesophageal cancer isn't exactly desirable either.