Ive squeezed 28's on my road racer (spesh turbo) It should really have 26's on. Its calliper.
I don't like riding it for more than 3 or 4 hours these days, because its not as comfortable as my endurance bikes. That's a combination of frame geo and tire width. Its generally ridden racing or fast paced and with a harder saddle (sella Italia) too that doesn't equate to comfort.
The other bikes are run with 32 (Spesh roubaix which I also find pretty harsh) then Rene herse, 44, 48, and 55mm. These are the set ups I like to ride on when not racing. Comfortable geo, loads of tire with the pressure fairly low. Anything over 6 hours then aero bars too. The endurance bikes have infinity saddles on that Im a great proponent of.