I write my 'a' with a squiggly bit (and my lower case 'r') – I guess that makes me a fundamentalist anti-Comic Sans. I can't see it without thinking CHURCH TOMBOLA or Primary School Parent Teacher Evening.
Traditionally serif fonts were easier to read in print, but low-resolution screens made them hard on the eye as the world moved online. Nowadays with high dpi screens and devices, there's not a lot in it. Sans Serif fonts always make for good headings, beyond a certain size, the serifs and fat lines start to unbalance the appearance of the text, even for a kerning ninja like moi (light variants can mitigate some of this to maintain elegance at larger sizes). Sans serif let you have nice clean lines at large sizes.
I still prefer Sans Serif on screen (I use Open Sans and Lato) but I can't read sans serif fonts in print. I am a certified font nerd though.
As the mothership is going through another re-branding exercise, we're back on Calibri which seems to be the font-ish expression of dull inoffensiveness. There's a custom font for headings which, like most custom fonts, looks like it was made on a (small) budget.