Having started training again in the recently improved weather, I've been considering the pathways of endurance fitness. Cardio-vascular improvements, and muscular strength are pretty obvious, but I got around to considering mytochondria, which are pretty odd things, in that they have their own independent DNA, and might even be considered as a sort of parasite.
They are responsible for metabolising fuel for muscular effort, and increase if you do a lot of endurance activity.
I was attracted by the closeness of the word to hypochondria. If there was some metabolite that made you feel good, like endorphins, I could use the term 'Mytochondriac' for someone obssessed with endurance exercise. This obviously leads to some Googling. One article I found was this.
http://sweatscience.com/brain-endurance-mitochondria-and-the-desire-to-exercise/What it says is that mytochondria in the brain increase (in lab rats) due to endurance exercise. This means that the brain can support more exercise without having to signal fatigue to stop muscles burning off the fuel it needs. The idea of a physically-trained brain is interesting, in that it might explain some of the growth in 'cycling wisdom' needed in extreme rides. It's an appealing hypothesis, which might explain some of the deeper appeal of long distances, especially as the presence of greater brain mitochondria might be linked to a desire to exercise more.
It also takes longer to grow mitochondria than to lose them, which is one of the attractions of keeping your nose to the treadmill.