You should just about be able to go cross-4 with 48 spokes notwithstanding the flange size, and cross-4 is least likely to crack flanges because it's virtually tangential. And the flanges are so large that there's plenty of space for 24 holes per side.
Rohloff really need thicker flanges and/or a steel shell option, though. You could have metal flanges and a CF main shell, like an old Nuke-Proof hub, and the weight wouldn't be much higher.