Thanks for the advice, Tatanab. Yes, it certainly looks like about 40 miles of sprawl before I get clear of Burbank (unless I take a meandering route through the canyon!). I may see if I can get someone to drive me out to there. After that I am thinking of heading through the Angeles National Forest, through Cedar Springs and Wrightwood, then turning SE towards San Bernadino, but if I can find somewhere to stay that would enable me to bypass the city then I'll do that instead.
Day 2, I envisage a sightly roundabout route to Temecula, passing through the San Jacinto Park and skirting Hemet. But I'll need to do some more detailed planning nearer the time.