I can find lots on this from Googling, but half of it's written by people who I'm not convinced know what they're talking about, and half of it is some years old. (I suspect 2008 is ancient history as far as this sort of thing goes).
On an Asus P7P55D-E motherboard with an i7 CPU, with a 64-bit OS, will two sticks of 4 GB RAM run quicker than four sticks of 2 GB, assuming all else is equal? Could there be a lot less heat as well? Assume budget isn't an issue (though it might be really).
The BIOS can do some clever auto overclocking, which I employ to some extent. The RAM I have at the moment is rated at 2000 MHz, but is more typically set to around 1500, or 1333 MHz with default settings. Fank you very much.