I've got an iPad2 (iOS 6.01) and two days ago I couldn't get the volume up button working. Volume down worked fine.
Now that is working again, but the power switch won't put it into stand-by/lock it. (And some how it flattened it's battery from 33% charged whilst left unused with the magnetic cover on).
I can still take screen shots using the home/power keys and turn it off by holding down the power key.
This is sounding like a weird software type thing - I don't think there's anything physically wrong with the buttons and it's not experienced any physical trauma by being dropped or anything.
Anyone else had these same issues?