the old ratios sound like 3x10 campag. If so, the answer is most probably 'no'. For many years long-arm campag mechs have had a large total capacity but have only a limited capacity for the largest sprocket, typically in the range 27-29.
You can try a hanger extender but the likely result is shifting that will be a bit below par on the smaller sprockets.
Yes, apart from very recent generations of Campagnolo 10-speed (which I think can go up to 30T), max officially supported sprocket size on the back was 29T with their 10-speed rear mechs - I can believe this is likely true in practice too, I have a medium cage 10-speed Chorus rear mech on my Mercian and there's really not a lot of clearance even with a 27T sprocket on the back (I'm running 12-27 and 50/34, but this is on a non-load carrying relatively lightweight road bike).
Either way, you'll certainly need a new front mech to be able shift a 48/34 nicely, if you've been running a front mech for a triple - the later 10-speed Campagnolo double mechs support both "standard" and "compact" chainring setups, though, and the Veloce ones can be had cheaply.
BTW which era of Campagnolo shifters are you using? The earlier ones (pre-2009-ish) aren't fully compatible with the more recent 10-speed rear mechs, due to weaker spring tension on the latter, but IMHO are still preferable to the newer nerfed "Powershift" shifters.