I use an Oregon, (450T) and I'm very happy with it indeed. I bought it as a multipurpose device: cycling, walking/hiking, skiing, driving and it does all of that well.
The most annoying feature (and that of many Garmin I think) is the time it takes to start up in a new location (can be 20 min to find itself). cycling, I find the size of the screen very useful, it is a very rare occasion that it gets its virtual knickers in a twist leaving the display NOT where you going (ie, with the turns at the bottom and the map the wrong way). The touch screen is great, as it works with gloves, although it isn't the most sensitive. Batteries are AA so spares are easy.
Clearly I haven't used an eTrex so can't compare, but my view is that the Oregon is top notch for a does-it-all device. If you do want to use it for driving (say in countries not covered in the Europe of standard car sat nav) don't expect it to be as good as the car dedicated devices, but it is entirely usable
ETA while McShroom may be right generally, the Oregon does work with normal style gloves, however thick.