I saw my brother on Tuesday evening, and we talked through his situation. He's been riding for about a year, and done a number of trail rdies in the UK, (the Tarka Trail in Devon/Dorset was one) and he's doing 25-30 miles in the Chilterns as training.
I think he will be OK is he gets out of the saddle from time to time, and they have mid-morning drinks stops and don't ride for more than 2 hours at a time. Daily mileage ranges from 30-58, or so, and most of the terrain across the Mekong Delta is flat.
I don't believe there is a hidden aspect of numb genitals. If there is, I can't help.
With no time to 'harden off' his seat, I advsied him to do what I did when I took on my first multi-day tour, which as to wear two pairs of shorts. <Opens can of worms> I know it is not the 'right' way, but he has no time to build up to it. It worked for me on the Paris to London ride, and may work for him. Thanks for all your suggestions.
Lycra Man