The ideal position would be to have my desk located near the router so I could plug straight into that (it is a NETWORK Attached Storage device, after all) but the router's downstairs and my desk is upstairs. You've got to set the NAS up on the router so it can do a software update, but after that, plugging it straight in seems to be all okay.
I have a QNAP TS-410 4 bay NAS as my main storage device. At the moment, it has two WD Red 4TB drives in it configured as RAID1. I do my backups via an Anker eSATA to SATA external hard drive docking station (about £35 on Amazon) and I have another pair of 4TB drives that I use. Every week, I back up the NAS and move the drive down to the safe in my studio. I retrieve the old one down there and plug it into the docking station ready for the next backup. That way, I have at least three perfect, primary copies of my data, plus whatever's on my computer and in the cloud. It's not bulletproof, but it's pretty solid.