Story-wise, Dune is essentially about a small planet rebelling against the schemings of a pan-galactic trade empire under the leadership of a young cult hero with powers he never knew he had, which is pretty much the same story as The Phantom Menace. And I know which of those two films I'd rather watch again.
A young cult hero is a member of one of those great families but also the premature culmination of a breeding programme that's being going on for centuries by a secretive group of super-nuns who have perfected a 'weirding way' of mind craft along with other forms of mind-technology elsewhere which is all needed because computers were banned many years ago by a 'Butlerian jihad' - hence they have trained 'computer guys' (mentats) and other weird organisations that do shit loads of weird stuff. Including interstellar space pilots who are mutated beyond normal form because they need that 'Old spice melange' that is needed to trip out on to get the mind to do those incredible calculations needed for space travel.
Don't forget that the 'old spice' is only found on the desert plate Dune and it's mixed up with those sandwort thingies and that the natives are hard as nails because they live in that harsh environment which trumps the special fighting abilities of the Emperor's Sardaukar - whose harsh planet of origin is like paradise compared to the Desert of Dune. Then there's the other major power-elites who've come along to fight for the only source of spice, plus CHOAM,
Tleilaxu, Bene-Gesserit... my head is beginning to hurt now.Yeah simples
You can boil any story down to Boy-meets-girl or whatever if you try hard enough - I struggle to think of a more complex series of books then Dune - though (as I've said elsewhere on here) - it does disappear somewhere up the copious backside of a giant half-human half Sandworm around book four and this person here, although he did struggle through the final ones - thought they got so complex they were almost incomprehensible by the end.
Anyway, sorry I'll STFU about Dune now