I used to be able to get away with Keynote, which is a nice presentation tool, does all the things you'd expect in a reasonable and intuitive manner. As with all software, they'd occasionally move or remove something to keep users on their toes, but generally creating a presentation was quick and easy, didn't involve days of sweary, frustrated mayhem, and even a fair amateur could produce something that looked, well, presentable.
Powerpoint is the exact opposite. Ill-suited for producing presentations, and even less suited for the numerous other applications people use it for. Basic functionality like resolution and device independence, support for PDFs, simply isn't there. That fucking ribbon, the way functions are randomly squirrelled away in the last place you would look, and constant changing focus than ensures whatever function you wanted next, moves instantly from one click away to several. Design templates, styles, etc. who knows, they're there, but are so complex, counterintuitive and dysfunctional, no one can use them.