I agree in the normal run of things I'd expect a frame manufacturer to have a better plan than that. I have fitted guides that are of similar ilk to frames, but of a different size so that they will accept pneumatic tubing as a snug fit. This works pretty well as a cable guide, but I don't think those fittings are the right size for that.
Re the iffy shifting; shimano 'road' 10s is the most finicky system IMHO. (Daft question; you do have a matched set of parts, right? Tiagra 4700 uses a different shift ratio to other 10s stuff...). On a tandem the amount of stretch you can get in the long cable between the system parts and a length of draggy housing is enough to mean that the gears won't run sweetly; ~1mm out at the mech is plenty enough to cause problems.
The cable housing run that can cause most trouble is the one at the rear mech. If it is (say) cut short so that the housing has a kink at the cable stop or the mech, it will most likely cause troubles. If the housing near the shifter is bad, it will also cause trouble, but it won't be quite the same.
If you run out of other ideas, go back and check the housing ends are prepped nicely, and/or try fitting a coated inner, or use different cable lube. 11s cable sets come with a little tail ferrule to fit in the rear mech; this fits most 10s mechs too and it makes the cable run smoother, so fitting one of those wouldn't be a bad idea either.
cheers