Just as another data point, I run a 46x19 winter gear at the moment, which I think is nearly 66" with 35mm cx tyres. This is in the fairly lumpy Cotswolds (there are certain hills I have to walk).
As my fitness, and the weather?, improves, I may go back to 46x17, but that will be with narrower tyres as well.
I use an adapted disc hub from velosolo which means I can swap sprockets using a 4mm allen key and have got no thread to strip.