Author Topic: Blimey! I'm on chemotherapy!  (Read 3899 times)

Wowbagger

  • Stout dipper
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Blimey! I'm on chemotherapy!
« on: 02 October, 2008, 07:10:38 pm »
Methotrexate, which is widely used in cancer treatment.

It's also used to treat rheumatoid arthritis, which is why I've got it, and when I went to my appointment this afternoon, to my great surprise the specialist decided that this is what they would prescribe. I gained the impression that it had been a decision taken jointly by several consultants in ...er ... consultation.

It's pretty nasty stuff. It's an immunosuppressant, reduces the activity of the bone marrow so can cause anaemia, can cause breathlessness and nausea. I've got to take a weekly dose.

But the worst thing of all is that it can affect liver functionality so I must curtail my alcoholic intake. This will be the hardest thing of all.

I haven't started taking it yet. I think I'll wait until the weekend is over. I've had a blood test (I've got to have fortnightly blood tests for a while) and I'll have to have a chest X-ray in the morning.
Quote from: Dez
It doesn’t matter where you start. Just start.

LEE

Re: Blimey! I'm on chemotherapy!
« Reply #1 on: 02 October, 2008, 07:14:02 pm »
I hope you take the time to do some private (internet) research before taking anything prescribed by anyone nowadays.  I don't trust anyone just becasue they have a stethescope around their neck any more.

Hope it's safe though and hope it works for you.

rogerzilla

  • When n+1 gets out of hand
Re: Blimey! I'm on chemotherapy!
« Reply #2 on: 02 October, 2008, 07:24:24 pm »
I think that's what my father's on, for the same reason.  It hasn't worked terribly well for him and it has side-effects (nausea, as well as the inability to drink).
Hard work sometimes pays off in the end, but laziness ALWAYS pays off NOW.

andygates

  • Peroxide Viking
Re: Blimey! I'm on chemotherapy!
« Reply #3 on: 02 October, 2008, 07:33:45 pm »
That's the stuff from the special pharmacy behind the sealed hatch that smells funny.

Cool! :thumbsup:
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pdm

  • Sheffield hills? Nah... Just potholes.
Re: Blimey! I'm on chemotherapy!
« Reply #4 on: 02 October, 2008, 07:42:33 pm »
Methotrexate is an excellent drug when properly used.  When used to damp down the autoimmune activity of Rheumatoid Arthritis the dose given is not as high as when given for cancer chemotherapy. The dose is a compromise between effective suppression of the disease and the risk of side effects. Not everybody who takes the drug experiences side effects. Rheumatoid Arthritis by itself can render the body immune suppressed to varying degrees and Methotrexate can sometimes even be beneficial if that is the case.
Some of the side effects of Methotrexate are also those of the disease - lung fibrosis, reduced immune response, liver dysfunction, marrow suppression... As you have said, tests are done to closely monitor the effects of the drug and it will be stopped at the first sign of any trouble and alternatives considered.
However, the majority of punters using Methotrexate tolerate it well and find it beneficial. (Double blind studies with Rheumatoid patients have shown the side effect rate to be about 10-15% - i.e. 1 in 8 or so users have felt that side effects were significant.)
I sincerely hope and pray that you are one of the majority and that the sacrifice of gentle teetotalism is worth it!

Eccentrica Gallumbits

  • Rock 'n' roll and brew, rock 'n' roll and brew...
Re: Blimey! I'm on chemotherapy!
« Reply #5 on: 02 October, 2008, 09:34:21 pm »
One of my clients is on it. She finds it helps her RA a lot but she does suffer from the side-effects and has days when she feels so ill she can't get out of bed. I hope it works for you without the side-effects.
My feminist marxist dialectic brings all the boys to the yard.


toekneep

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Re: Blimey! I'm on chemotherapy!
« Reply #6 on: 02 October, 2008, 09:39:07 pm »
Could be a turning point in more ways than one WB. I sometimes think that it would take a medical requirement to change my drinking habits and that such a situation might not be all bad. I wish you well.

Charlotte

  • Dissolute libertine
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Re: Blimey! I'm on chemotherapy!
« Reply #7 on: 02 October, 2008, 10:01:38 pm »
Depending on how you look at it, this is either rather good or jolly bad news.  I hope that you treat it as the former and that the effects it has on you are positive.

Teetotalism doesn't sound like it's completely necessary, just a lot more moderation.  Which is a bummer, but undoubtedly much better than giving it up entirely. 

I'll buy you an alcohol free Cobra when we next have a curry.  It's not all that bad...
Commercial, Editorial and PR Photographer - www.charlottebarnes.co.uk

Re: Blimey! I'm on chemotherapy!
« Reply #8 on: 02 October, 2008, 10:04:45 pm »
Fingers crossed your bod doesn't mind it too much and it kicks the RA's ass.

Mike J

  • Guinea Pig Person
Re: Blimey! I'm on chemotherapy!
« Reply #9 on: 02 October, 2008, 10:07:10 pm »
My mum is on this (or has been),  I lose track of what she has been on, however I don't think she had any side effects.

Jaded

  • The Codfather
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Re: Blimey! I'm on chemotherapy!
« Reply #10 on: 02 October, 2008, 10:47:54 pm »
Beardy wierdy manly hugs from over this way.   :thumbsup:

(OK, I know I haven't got a beard, and I am not wierd, but you are!   ;) )

PS - The Slad Valley calls.
It is simpler than it looks.

Wowbagger

  • Stout dipper
    • Stuff mostly about weather
Re: Blimey! I'm on chemotherapy!
« Reply #11 on: 02 October, 2008, 11:03:18 pm »
It really was quite a surprise to be prescribed this stuff. I've not actually been diagnosed with rheumatoid arthritis. I've got "palindromic" arthritis / rheumatism. Apparently this can often be a forerunner of RA, is still considered an autoimmune disease and on bad days can be very debilitating, but hitherto has shown no sign of permanent joint damage. RA attacks the cartilage and this shows up on X-rays.

I've actually been pretty well in recent weeks, since my last steroid injection, which was mid-August. In my last consultant's appointment, which was a couple of months ago, we discussed the possibility of changing from Plaquinil (quinine) to sulfasalazine, but evidently they decided not to bother. All these drugs are known as DMARDS (disease modifying antirheumatic drugs) as opposed to NSAIDS (non-steroidal anti-inflammatory drugs). The former slow / prevent the development of the disease, the latter reduce the symptoms.

If the booze has to stop, it has to stop. It's a bugger, but there you are. I'll just have to spend more time cycling instead. And, of course, count the pints I haven't drunk and save up for a new bike.

I think I quite fancy a Ti single speed of the type ridden by the BD (ret'd).  :demon:

Oh, and Jaded: the Slad Valley is a place with Old Spot and the finest pub lunch I have ever had, in Laurie Lee's local - I can't remember the name of the pub. I think I had better avoid it.
Quote from: Dez
It doesn’t matter where you start. Just start.

Re: Blimey! I'm on chemotherapy!
« Reply #12 on: 03 October, 2008, 08:08:57 am »
WOW  try it and you judge if it's helping, not the Doctor ;)
"100% PURE FREAKING AWESOME"

Re: Blimey! I'm on chemotherapy!
« Reply #13 on: 03 October, 2008, 08:34:39 am »
I hope you take the time to do some private (internet) research before taking anything prescribed by anyone nowadays.  I don't trust anyone just becasue they have a stethescope around their neck any more.

Hope it's safe though and hope it works for you.
Bearing in mind that anybody (qualified or not) can post anything on the internet (peer reviewed detailed research or vague unsubstatiated unqualified junk) which is often hard to separate, I would rather listen carefully to the specialist that knows the patient and the condition, which is clearly what W is doing.

Hope it has the desired result, W

hellymedic

  • Just do it!
Re: Blimey! I'm on chemotherapy!
« Reply #14 on: 03 October, 2008, 09:54:49 am »
I hope you take the time to do some private (internet) research before taking anything prescribed by anyone nowadays.  I don't trust anyone just becasue they have a stethescope around their neck any more.

Hope it's safe though and hope it works for you.
Bearing in mind that anybody (qualified or not) can post anything on the internet (peer reviewed detailed research or vague unsubstatiated unqualified junk) which is often hard to separate, I would rather listen carefully to the specialist that knows the patient and the condition, which is clearly what W is doing.

Hope it has the desired result, W

Agreed. Wow has posted that several doctors have conferred about his case and we really aren't more qualified than they are. The decision to start methotrexate is not undertaken lightly.

Hope your treatment helps you!

Re: Blimey! I'm on chemotherapy!
« Reply #15 on: 03 October, 2008, 10:00:58 am »
I hope you take the time to do some private (internet) research before taking anything prescribed by anyone nowadays

I quite agree. After all, it only takes 7 or 8 years of work and study in a specialist area to become a consultant following a 6 year medical degree. A quick browse of the internet and a random selection of advice like yours is obviously going to be much more informed.  ::-)

(Hope it works well for you wow).


David Martin

  • Thats Dr Oi You thankyouverymuch
Re: Blimey! I'm on chemotherapy!
« Reply #16 on: 03 October, 2008, 10:48:35 am »
Methotrexatee .. MMmm.. we use it in the lab as it does really interesting stuff to cells. At much higher doses than you will be taking, no doubt.

Talk to the specialists. Ask them about side effects, contra-indications etc.

As H. has said, they do have teh knowledge and experience.

..d
"By creating we think. By living we learn" - Patrick Geddes

pdm

  • Sheffield hills? Nah... Just potholes.
Re: Blimey! I'm on chemotherapy!
« Reply #17 on: 03 October, 2008, 01:41:33 pm »
It really was quite a surprise to be prescribed this stuff. I've not actually been diagnosed with rheumatoid arthritis. I've got "palindromic" arthritis / rheumatism. Apparently this can often be a forerunner of RA, is still considered an autoimmune disease and on bad days can be very debilitating, but hitherto has shown no sign of permanent joint damage. RA attacks the cartilage and this shows up on X-rays.

Quite right but it is probably worth mentioning that in today's rheumatology climate the appearance of erosions and cartilage destruction on X-Rays is deemed a failure of treatment and all efforts these days are directed to prevent progression of disease to this level of permanent damage and debility for as long as possible. Of course, severe cases and cases where treatment is ignored or not tolerated will progress but, hopefully, these will be a minority especially with the much wider armamentarium of disease modifying drugs now available, several of which have been mentioned in posts above.
For interest: high frequency diagnostic Ultrasound and MRI  with so-called microscopy coils are more sensitive in detecting the earliest anatomical abnormalities in erosive arthropathies..
I would assume that the decision to embark on Methotrexate would have been on reasonable grounds such as a worsening or insufficient resolution of either symptoms or the underlying serum markers for autoimmune disease (of which the commonly used are anti-CCP: cyclic citrullinated peptide antibodies, COMP: cartilage oligomeric matrix protein, IL1-alpha: interleukin 1-alpha, RF: rheumatoid factor) or both with the use of steroids (which also needs to be used with caution due to long term side effects)

Tiger

Re: Blimey! I'm on chemotherapy!
« Reply #18 on: 03 October, 2008, 02:01:22 pm »
My medical colleagues of the internet practice once again provide sound advice, with which I mostlly concur.

However Wow - as you know yourself - those so called doctors in the NHS are just tools of the drug companies - that's why they have put you on such a strong drug before fully exploring the alternatives such as earcones. Hopi earcones have been used successfully by North American Indians to treat many ailments inclusing RA for centuries. (And they are available in any Holland and Barrett).


Wowbagger

  • Stout dipper
    • Stuff mostly about weather
Re: Blimey! I'm on chemotherapy!
« Reply #19 on: 05 October, 2008, 10:46:31 pm »
Well, a mate of mine has just left and between us we have shifted quite a bit of beer. Tomorrow evening I start on the methotrexate. I thought about this and decided that a Monday evening would be a good time to take my weekly dose. I'll steer clear of the beer all week and maybe have a couple of pints on Friday or Saturday evening. I was told by the specialist that a couple of pints a week would be OK. I've no idea what the science says, but common sense tells me (I had to ask Mrs Wow because I haven't got any) that this will mean the least conflict between drugs & booze.
Quote from: Dez
It doesn’t matter where you start. Just start.

Re: Blimey! I'm on chemotherapy!
« Reply #20 on: 06 October, 2008, 04:15:44 pm »
My medical colleagues of the internet practice once again provide sound advice, with which I mostlly concur.

However Wow - as you know yourself - those so called doctors in the NHS are just tools of the drug companies - that's why they have put you on such a strong drug before fully exploring the alternatives such as earcones. Hopi earcones have been used successfully by North American Indians to treat many ailments inclusing RA for centuries. (And they are available in any Holland and Barrett).

PMROFL
I think you'll find it's a bit more complicated than that.

Jakob

Re: Blimey! I'm on chemotherapy!
« Reply #21 on: 06 October, 2008, 11:59:43 pm »
Well, a mate of mine has just left and between us we have shifted quite a bit of beer. Tomorrow evening I start on the methotrexate. I thought about this and decided that a Monday evening would be a good time to take my weekly dose. I'll steer clear of the beer all week and maybe have a couple of pints on Friday or Saturday evening. I was told by the specialist that a couple of pints a week would be OK. I've no idea what the science says, but common sense tells me (I had to ask Mrs Wow because I haven't got any) that this will mean the least conflict between drugs & booze.

Just drop the booze. Seriously..your body will thank you for it.

Wowbagger

  • Stout dipper
    • Stuff mostly about weather
Re: Blimey! I'm on chemotherapy!
« Reply #22 on: 07 October, 2008, 12:04:25 am »
Well, I had my first batch of tablets tonight and then went to the pub ... to drink ginger beer.

It was OK. The only thing wrong was that on small bottle of ginger beer cost £1.90. >:(
Quote from: Dez
It doesn’t matter where you start. Just start.

Re: Blimey! I'm on chemotherapy!
« Reply #23 on: 07 October, 2008, 12:05:05 am »
I think my mum is on the same tablets.

Re: Blimey! I'm on chemotherapy!
« Reply #24 on: 07 October, 2008, 12:18:10 am »
This is the site my GP uses for info sheets that I've had in the past...
Methotrexate

Hope it goes well Wowb...

Andy
Cycle and recycle.   SS Wilson