The main issue I've had with my TRP Spyres is that getting replacement pads is a right faff. The TRP ones that come with the calipers are great, but noone sells them. I've tried some from uber bike, and from nuke proof, and neither has been as good as the ones that come with the caliper. I've just had something go wrong with the front caliper on my bike, I'm not sure what it is. I've ordered a new one, will then service the old one and use it as a spare, or put it on the new bike.
J