I've just rushed him into the vets as an emergency, since he became a lot worse very fast. Earlier on he was a bit inactive, but still wandered around, and complained about not being let out. When I went upstairs recently, he was completely lethargic. If I stood him up, he lay straight back down, and didn't make his normal little meow "Hello". He wasn't even purring much. I realise purring doesn't necessarily indicate a happy cat, but Talisker will purr at the drop of a hat, not doing it is very unusual.
Anyway, the vets looked at him, and he's clearly dehydrated and needs to go on a drip. He's lost about 0.3-0.4 kg in weight, his temperature is low, and he seems to have some tenderness in his belly (although not much, since I did a brief check for this sort of thing myself). The vet is obviously suspicious about Pancreatitis, and is going to do one of the Panreatic Lipase tests (although I forget which one exactly). Since he had almost identical symptoms in February (only without the low temperature), it could be something re-occurring, so finding out what would be useful.
He should call back later today and give me a status report.