I can see the Ibis and the Novotel out of the office window. I can also see whatever cruise ships are in (none at the moment) and a ruddy great pile of containers. You also have the DeVere grand harbour, and whatever the post house is called this week, but its a bit ratty.
My office is just North of the railway station, but the hotels mentioned are all much closer to the docks themselves.
If you want more Southampton specific info, let me know, I work for the City Council.
Ibis and Novotel have fair websites, and you can see what's what, online. Ibis also do a little book of all their hotels, handy to have in the car if you may need to find a hotel in an unknown area.
Wombat