I always had the impression, when doing a mass clean of my 10 or so Rotring pens (I worked in a drawing office) that if you dripped one drop of Rotring ink into the Pacific Ocean, the whole thing would turn black. There was always this semi-macho thing abotu using the 0.1, and when it all changed sizes, so we started at 0.13, then .18, .25, .35 (I'm open to correction here!) and so on up to the monster 2mm one that you could stand on end, if careful, it was soemhow less cool than using the 0.1 for your construction lines.
I vaguely recall there was a "lightweight" soapy cleaner, and a more fearsome stuff introduced later, for dried up gunge.
However, as you say, letterpress ink is a different world... I have seen it, but have more familiarity with offset litho ink, and cleaning the blankets with MEK.... Currently sat about 10metres from where that all used to happen 35plus years ago, having changed jobs back to work in the same LA!