I've a 725 framed CdF, although it's the earlier QR version. I've used it almost exclusively for touring on and light off road (front and rear racks, four panniers, full mudguards).
I love it. The ride is smooth and feels planted. It's a heavy frame, particularly the steel fork, but I've never noticed it when riding. With the touring weight, the flex of the frame is certainly noticeable, so if that's what you're looking for, you'll get it. No build quality issues to report, including from several of my friends who also have 725 CdFs.
I don't buy that thru axles make much difference. Have a look at the Peak Torque videos on YouTube. There's one on thru axles. That said, I'm building up an 853 CdF at the moment which has thru-axles. They're not a factor that would influence my buying. It's just a great bike.