A difficulty is that cassettes with large sprockets at one end, such as the ones you’re considering, have pointlessly small sprockets at the other end in these days of 10- and 11-speed systems. So you’re usually forced to waste gears (and chainline freedom) on an 11T and 12T sprocket. These are effectively useless for the riding you describe (and much else).
Still, your basic idea that larger sprockets make larger chainrings viable is self-evidently true. Whether it works well for you depends on the fine detail.
I run a somewhat similar set-up in that I have 38T and 49T chainrings with an 8-speed 13–26T cassette. This gives close ratios everywhere despite the low sprocket count, a top gear designed to be used regularly, a low enough bottom gear for my purposes (this is highly personal), and a good chain angle most of the time. However, I often ride in groups. When I’m on my own on a long ride, the chain angle isn’t ideal because then my cruising speed is too low, especially into the wind. Still, it’s better than the typical compact-double arrangement, and most cyclists don’t recognise a problem with that.
You can optimise gearing to the nth degree but it will always be a compromise. When I’m blasting around Longchamp with packs of marauding racers, I’d prefer a 53T chainring for the extra efficiency and better chain angle that would bring. But it would be hopelessly large the rest of time. On solo rides I’d prefer a 46T. The compromise I have is about the best I can do but it remains a compromise.
