The Order of the Stick is ver' good - it's based around
Dungeons & Dragons but you don't need any knowledge of RPGs to get the jokes. Probably best to start with the early strips, as there is a running plot.
Similarly,
The Battle For Gobwin Knob, also hosted on that site is good, and full of internet meme based gags, but it's more of an online graphic novel, so read it from the beginning.
Sluggy Freelance is worth a read. It has long-running plot arcs (some of which are better than others) interspersed with happy one-off gags. It's best to start with earlier strips to understand who the characters are, and quite why there is a psychotic mini-lop rabbit with a switchblade and a ferret with attention deficit-ooh, hey, shiny!
Sample strips:
http://sluggy.com/daily.php?date=010416http://pics.sluggy.com/daily.php?date=010417http://pics.sluggy.com/daily.php?date=010418http://pics.sluggy.com/daily.php?date=010419http://pics.sluggy.com/daily.php?date=010420Otherwise, for pant-wetting had-me-laughing-out-loud-at-work-and-getting-funny-looks, can I recommend
DM of the Rings? Someone has taken screenshots of the
Lord of the Rings movies and re-scripted them as a
D&D campaign, and it's
hilarious!
There. That should stop you getting any work done by mid-May.